Ensemble learning is a popular technique for enhancing the performance of machine learning algorithms. It is used to capture a complex model space with simple hypotheses which are often significantly easier to learn, or to increase the accuracy of an otherwise unstable procedure [see 14,27,29,andreferencestherein].

What NAD+? Here's how it works in your body, why it matters, and if supplementation is worth the hype. It's more than likely that the NAD+ supplement craze has already crossed your path. The Biebers have infused it. Joe Rogan has podcasted about it. Gwyneth Paltrow swears by it and, of course, sells her own Youth-Boost NAD+ Peptide Rich Cream . NAD+ (short for nicotinamide adenine dinucleotide) is a coenzyme that your body makes naturally--it contributes to energy production and immune function, among other things. It reflects a broader shift in how people think about healthy aging and extending their healthspan overall .

Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013-2017), we tell our story of developing, evaluating, and implementing a machine learning-based approach for covariate adjustment. We provide the rationale for as well as the practical concerns with such an approach for estimating marginal effects. Using schematics, we illustrate our procedure: targeted machine learning estimation (TMLE) with Adaptive Pre-specification. Briefly, sample-splitting is used to data-adaptively select the combination of estimators of the outcome regression (i.e., the conditional expectation of the outcome given the trial arm and covariates) and known propensity score (i.e., the conditional probability of being randomized to the intervention given the covariates) that minimizes the cross-validated variance estimate and, thereby, maximizes empirical efficiency. We discuss our approach for evaluating finite sample performance with parametric and plasmode simulations, pre-specifying the Statistical Analysis Plan, and unblinding in real-time on video conference with our colleagues from around the world. We present the results from applying our approach in the primary, pre-specified analysis of 8 recently published trials (2022-2024). We conclude with practical recommendations and an invitation to implement our approach in the primary analysis of your next trial.

Aerial Vision-and-Language Navigation (VLN) aims to enable unmanned aerial vehicles (UAVs) to interpret natural language instructions and navigate complex urban environments using onboard visual observation. This task holds promise for real-world applications such as low-altitude inspection, search-and-rescue, and autonomous aerial delivery. Existing methods often rely on panoramic images, depth inputs, or odometry to support spatial reasoning and action planning. These requirements increase system cost and integration complexity, thus hindering practical deployment for lightweight UAVs. We present a unified aerial VLN framework that operates solely on egocentric monocular RGB observations and natural language instructions. The model formulates navigation as a next-token prediction problem, jointly optimizing spatial perception, trajectory reasoning, and action prediction through prompt-guided multi-task learning. Moreover, we propose a keyframe selection strategy to reduce visual redundancy by retaining semantically informative frames, along with an action merging and label reweighting mechanism that mitigates long-tailed supervision imbalance and facilitates stable multi-task co-training. Extensive experiments on the Aerial VLN benchmark validate the effectiveness of our method. Under the challenging monocular RGB-only setting, our model achieves strong results across both seen and unseen environments. It significantly outperforms existing RGB-only baselines and narrows the performance gap with state-of-the-art panoramic RGB-D counterparts. Comprehensive ablation studies further demonstrate the contribution of our task design and architectural choices.

Building upon Salas et al.'s "Big Five" teamwork model, we operationalize five core components as independently configurable mechanisms: shared mental models, team leadership, team orientation, trust networks, and mutual monitoring. Our architecture dynamically recruits 2-4 specialist agents and employs structured four-phase deliberation with adaptive component selection. Evaluation across eight medical benchmarks encompassing 11,545 questions demonstrates TeamMedAgents achieves 77.63% overall accuracy (text-based: 81.30%, vision-language: 66.60%). Systematic ablation studies comparing three single-agent baselines (Zero-Shot, Few-Shot, CoT) against individual teamwork components reveal task-specific optimization patterns: shared mental models excel on knowledge tasks, trust mechanisms improve differential diagnosis, while comprehensive integration degrades performance. Adaptive component selection yields 2-10 percentage point improvements over strongest baselines, with 96.2% agent convergence validating structured coordination effectiveness. TeamMedAgents establishes principled methodology for translating human teamwork theory into multi-agent systems, demonstrating that evidence-based collaboration patterns enhance AI performance in safety-critical domains through modular component design and selective activation strategies.

Intensive care unit (ICU) data are highly irregular, heterogeneous, and temporally fragmented, posing challenges for generalizable clinical prediction. We present PULSE-ICU, a self-supervised foundation model that learns event-level ICU representations from large-scale EHR sequences without resampling or manual feature engineering. A unified embedding module encodes event identity, continuous values, units, and temporal attributes, while a Longformer-based encoder enables efficient modeling of long trajectories. PULSE-ICU was fine-tuned across 18 prediction tasks, including mortality, intervention forecasting, and phenotype identification, achieving strong performance across task types. External validation on eICU, HiRID, and P12 showed substantial improvements with minimal fine-tuning, demonstrating robustness to domain shift and variable constraints. These findings suggest that foundation-style modeling can improve data efficiency and adaptability, providing a scalable framework for ICU decision support across diverse clinical environments.

Despite high performance on clinical benchmarks, large language models may reach correct conclusions through faulty reasoning, a failure mode with safety implications for oncology decision support that is not captured by accuracy-based evaluation. In this two-cohort retrospective study, we developed a hierarchical taxonomy of reasoning errors from GPT-4 chain-of-thought responses to real oncology notes and tested its clinical relevance. Using breast and pancreatic cancer notes from the CORAL dataset, we annotated 600 reasoning traces to define a three-tier taxonomy mapping computational failures to cognitive bias frameworks. We validated the taxonomy on 822 responses from prostate cancer consult notes spanning localized through metastatic disease, simulating extraction, analysis, and clinical recommendation tasks. Reasoning errors occurred in 23 percent of interpretations and dominated overall errors, with confirmation bias and anchoring bias most common. Reasoning failures were associated with guideline-discordant and potentially harmful recommendations, particularly in advanced disease management. Automated evaluators using state-of-the-art language models detected error presence but could not reliably classify subtypes. These findings show that large language models may provide fluent but clinically unsafe recommendations when reasoning is flawed. The taxonomy provides a generalizable framework for evaluating and improving reasoning fidelity before clinical deployment.

We present Tell Me, a mental well-being system that leverages advances in large language models to provide accessible, context-aware support for users and researchers. The system integrates three components: (i) a retrieval-augmented generation (RAG) assistant for personalized, knowledge-grounded dialogue; (ii) a synthetic client-therapist dialogue generator conditioned on client profiles to facilitate research on therapeutic language and data augmentation; and (iii) a Well-being AI crew, implemented with CrewAI, that produces weekly self-care plans and guided meditation audio. The system is designed as a reflective space for emotional processing rather than a substitute for professional therapy. It illustrates how conversational assistants can lower barriers to support, complement existing care, and broaden access to mental health resources. To address the shortage of confidential therapeutic data, we introduce synthetic client-therapist dialogue generation conditioned on client profiles. Finally, the planner demonstrates an innovative agentic workflow for dynamically adaptive, personalized self-care, bridging the limitations of static well-being tools. We describe the architecture, demonstrate its functionalities, and report evaluation of the RAG assistant in curated well-being scenarios using both automatic LLM-based judgments and a human-user study. This work highlights opportunities for interdisciplinary collaboration between NLP researchers and mental health professionals to advance responsible innovation in human-AI interaction for well-being.

Mental health communication in India is linguistically fragmented, culturally diverse, and often underrepresented in clinical NLP. Current health ontologies and mental health resources are dominated by diagnostic frameworks centered on English or Western culture, leaving a gap in representing patient distress expressions in Indian languages. We propose cross-linguistic graphs of patient stress expressions (CL-PDE), a framework for building cross-lingual mental health ontologies through graph-based methods that capture culturally embedded expressions of distress, align them across languages, and link them with clinical terminology. Our approach addresses critical gaps in healthcare communication by grounding AI systems in culturally valid representations, allowing more inclusive and patient-centric NLP tools for mental health care in multilingual contexts.